G6PD Deficiency in Neonatal Jaundice

Abstract

INTRODUCTION: Neonatal jaundice is one of the important problems encountered by the newborn in the first week after birth, the etiology of which is very diverse and sometimes no cause can be detected. It can result in death if the patients differ in their clinics and are not diagnosed early. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, which is one of the etiological causes of neonatal jaundice, is among the causes of neonatal jaundice in our country. In this study, it was aimed to examine the effect of G6PD enzyme on jaundice in newborns followed up in our hospital for jaundice. METHODS: The study group consisted of 100 icteric babies who were followed-up XXXXX Hospital City Neonatology Department with the diagnosis of jaundice. RESULTS: In our study, the most common causes of jaundice in 100 babies diagnosed with jaundice were ABO incompatibility in 31(31%), jaundice due to G6PD deficiency in 10(10%) babies. It was observed that total bilirubin levels in babies with G6PD deficiency decreased significantly over a longer period of time compared to babies without enzyme deficiency. No significant difference was found in the other parameters of the patients. Of the babies with G6PD deficiency, 52(52%) were boys and 48(48%) were girls. No statistically significant difference was DISCUSSION AND CONCLUSION: While investigating the etiology of jaundice in newborns, it would be appropriate to check the G6PD levels in babies, and it should be considered that jaundice may improve in a long time in babies with low G6PD levels, and the necessary treatment should be planned in this way.

Keywords

• glucose-6-phosphate-dehydrogenase deficiency
• jaundice
• neonatal