Evaluation of the VP22 gene adjuvant for enhancement of DNA vaccine against somatostatin in mice

Li. Han; A.X. Liang; J. Zhang; M. Fang; G.H. Hua; L. Sang; L.Y. Geng; H.R. Wang; L.G. Yang

Animal (Jan 2008)

Evaluation of the VP22 gene adjuvant for enhancement of DNA vaccine against somatostatin in mice

Li. Han,
A.X. Liang,
J. Zhang,
M. Fang,
G.H. Hua,
L. Sang,
L.Y. Geng,
H.R. Wang,
L.G. Yang

Affiliations

Li. Han: Key lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070 PRChina
A.X. Liang: Key lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070 PRChina
J. Zhang: Key lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070 PRChina
M. Fang: Key lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070 PRChina
G.H. Hua: Key lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070 PRChina
L. Sang: Key lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070 PRChina
L.Y. Geng: Key lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070 PRChina
H.R. Wang: Key lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070 PRChina
L.G. Yang: Key lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070 PRChina

Journal volume & issue: Vol. 2, no. 11
pp. 1569 – 1574

Abstract

Read online

Somatostatin (SS) is a hormone that inhibits the secretion of growth hormone. Immunization against SS can promote the growth of animals. A novel SS-VP22 fused vaccine, pEGS2SS-V, was constructed from pEGS2SS plasmid with a VP22 gene fragment. Two times of immunization with pEGS2SS-V-induced anti-SS antibodies in mice. Compared with mice immunized with pEGS2SS and 0.85% saline, the growth performance of mice immunized with pEGS2SS-V was increased by 14.1% (P < 0.05) and 48.4% (P < 0.01) on the 2nd week after the first vaccination, respectively. The results indicated that the effects of the somatostatin DNA vaccine could be improved effectively by VP22 gene adjuvant.

Published in Animal

ISSN: 1751-7311 (Print); 1751-732X (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Agriculture: Animal culture
Website: https://www.journals.elsevier.com/animal/

About the journal

Abstract

Keywords