Correlation between liver fat content with dyslipidemia and Insulin resistance

Abstract

Total 33 obese patients were studied to determine correlation in between liver fat content with dyslipidemia and insulin resistance. Liver and spleen attenuation measurements were taken with three regions of interests (ROIs) from the liver and two ROIs from the spleen. Hepatic attenuation indices were measured as follows: (1) Hepatic parenchymal attenuation (CT LP ); (2) liver to spleen attenuation ratio (LS ratio ); and (3) difference between hepatic and splenic attenuation (LS dif ). Bivariate correlation analysis showed moderate but statistically significant negative correlation between CT LP , LS ratio , and LS dif with body mass index, triglyceride, fasting plasma sugar, fasting plasma insulin, homeostasis model assessment-insulin resistance (HOMA IR), 2 h oral glucose tolerance test (OGTT), and statistically significant positive correlation with high density lipoprotein. Nonalcoholic fatty liver disease (NAFLD) is closely associated with features of the metabolic syndrome. The amount of intrahepatic fat closely correlates with the number of metabolic syndrome features. The values of CT LP , LS ratio , and LS dif demonstrate strong inverse correlations with degree of steatosis.

Keywords

• Hepatic attenuation indices
• homeostasis model of assessment insulin resistance
• nonalcoholic fatty liver disease
• waist-hip ratio