Targeting gliomas with STAT3-silencing nanoparticles

Abstract

Glioblastoma is an aggressive brain tumor with poor prognosis. The brain is protected by the blood–brain barrier, which precludes transport of chemotherapeutics. We developed nanoparticles that achieve delivery of small-interfering RNA against Stat3 after systemic administration. Nanoparticles combined with radiation inhibited tumor progression and elicited anti-glioblastoma immunity in mice.

Keywords

• glioma; nanoparticles
• systemic drug-delivery
• targeted-therapy
• immunotherapy