Nature Communications (Aug 2022)
Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade
- Ying Zhang,
- Raghava N. Sriramaneni,
- Paul A. Clark,
- Justin C. Jagodinsky,
- Mingzhou Ye,
- Wonjong Jin,
- Yuyuan Wang,
- Amber Bates,
- Caroline P. Kerr,
- Trang Le,
- Raad Allawi,
- Xiuxiu Wang,
- Ruosen Xie,
- Thomas C. Havighurst,
- Ishan Chakravarty,
- Alexander L. Rakhmilevich,
- Kathleen A. O’Leary,
- Linda A. Schuler,
- Paul M. Sondel,
- Kyungmann Kim,
- Shaoqin Gong,
- Zachary S. Morris
Affiliations
- Ying Zhang
- Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison
- Raghava N. Sriramaneni
- Department of Human Oncology, University of Wisconsin-Madison
- Paul A. Clark
- Department of Human Oncology, University of Wisconsin-Madison
- Justin C. Jagodinsky
- Department of Human Oncology, University of Wisconsin-Madison
- Mingzhou Ye
- Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison
- Wonjong Jin
- Department of Human Oncology, University of Wisconsin-Madison
- Yuyuan Wang
- Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison
- Amber Bates
- Department of Human Oncology, University of Wisconsin-Madison
- Caroline P. Kerr
- Department of Human Oncology, University of Wisconsin-Madison
- Trang Le
- Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison
- Raad Allawi
- Department of Human Oncology, University of Wisconsin-Madison
- Xiuxiu Wang
- Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison
- Ruosen Xie
- Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison
- Thomas C. Havighurst
- Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison
- Ishan Chakravarty
- Department of Human Oncology, University of Wisconsin-Madison
- Alexander L. Rakhmilevich
- Department of Human Oncology, University of Wisconsin-Madison
- Kathleen A. O’Leary
- Department of Comparative Biosciences, University of Wisconsin-Madison
- Linda A. Schuler
- Department of Comparative Biosciences, University of Wisconsin-Madison
- Paul M. Sondel
- Department of Human Oncology, University of Wisconsin-Madison
- Kyungmann Kim
- Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison
- Shaoqin Gong
- Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison
- Zachary S. Morris
- Department of Human Oncology, University of Wisconsin-Madison
- DOI
- https://doi.org/10.1038/s41467-022-32645-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Radiotherapy can activate an in situ vaccine response and promote response to immune checkpoint inhibitors. Here the authors design a multifunctional nanoparticle to enhance tumor antigen presentation and modulate the tumor immune microenvironment following radiotherapy, showing improved anti-tumor immune responses in radiotherapy-treated tumors when combined with immune checkpoint inhibitors.
