Innovative Surgical Science (Apr 2017)

Septic cardiomyopathy: evidence for a reduced force-generating capacity of human atrial myocardium in acute infective endocarditis

  • Buschmann Katja,
  • Chaban Ryan,
  • Emrich Anna Lena,
  • Youssef Marwan,
  • Kornberger Angela,
  • Beiras-Fernandez Andres,
  • Vahl Christian Friedrich

Journal volume & issue
Vol. 2, no. 2
pp. 81 – 87


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This study analyzes the myocardial force-generating capacity in infective endocarditis (IE) using an experimental model of isolated human atrial myocardium. In vivo, it is difficult to decide whether or not alterations in myocardial contractile behavior are due to secondary effects associated with infection such as an altered heart rate, alterations of preload and afterload resulting from valvular defects, and altered humoral processes. Our in vitro model using isolated human myocardium, in contrast, guarantees exactly defined experimental conditions with respect to preload, afterload, and contraction frequency, thus not only preventing confounding by in vivo determinants of contractility but also excluding effects of other factors associated with sepsis, hemodynamics, humoral influences, temperature, and medical treatment.