Nature Communications (Feb 2021)

A rotary mechanism for allostery in bacterial hybrid malic enzymes

  • Christopher John Harding,
  • Ian Thomas Cadby,
  • Patrick Joseph Moynihan,
  • Andrew Lee Lovering

DOI
https://doi.org/10.1038/s41467-021-21528-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

Bacterial malic enzymes (ME) transform malate to pyruvate. One group, hybrid ME enzymes, are regulated by acetyl-CoA, linking the enzyme activity to the metabolic state of the cell. Structures of a representative hybrid ME MaeB reveal large conformational rearrangements that provide insight into the mechanism of allosteric inhibition by acetyl-CoA.