Multilayered regulations of alternative splicing, NMD, and protein stability control temporal induction and tissue-specific expression of TRIM46 during axon formation

John K. Vuong; Volkan Ergin; Liang Chen; Sika Zheng

doi:10.1038/s41467-022-29786-4

Nature Communications (Apr 2022)

Multilayered regulations of alternative splicing, NMD, and protein stability control temporal induction and tissue-specific expression of TRIM46 during axon formation

John K. Vuong,
Volkan Ergin,
Liang Chen,
Sika Zheng

Affiliations

John K. Vuong: Division of Biomedical Sciences, School of Medicine, University of California, Riverside
Volkan Ergin: Division of Biomedical Sciences, School of Medicine, University of California, Riverside
Liang Chen: Department of Quantitative and Computational Biology, University of Southern California
Sika Zheng: Division of Biomedical Sciences, School of Medicine, University of California, Riverside

DOI: https://doi.org/10.1038/s41467-022-29786-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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The genetic control underlying axon formation in neurons is unknown. Here, the authors report that neural-specific induction of TRIM46, one of the earliest axonal markers, is regulated by alternative splicing, NMD, and protein stability controls.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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