Advances in probing single biomolecules: From DNA bases to glycans

Baofei Hou; Teng Zhang; Huixia Yang; Xu Han; Liwei Liu; Linfei Li; Cesare Grazioli; Xu Wu; Nan Jiang; Yeliang Wang

doi:10.1002/idm2.12106

Interdisciplinary Materials (Jul 2023)

Advances in probing single biomolecules: From DNA bases to glycans

Baofei Hou,
Teng Zhang,
Huixia Yang,
Xu Han,
Liwei Liu,
Linfei Li,
Cesare Grazioli,
Xu Wu,
Nan Jiang,
Yeliang Wang

Affiliations

Baofei Hou: MIIT Key Laboratory for Low‐Dimensional Quantum Structure and Devices, School of Integrated Circuits and Electronics Beijing Institute of Technology Beijing China
Teng Zhang: MIIT Key Laboratory for Low‐Dimensional Quantum Structure and Devices, School of Integrated Circuits and Electronics Beijing Institute of Technology Beijing China
Huixia Yang: MIIT Key Laboratory for Low‐Dimensional Quantum Structure and Devices, School of Integrated Circuits and Electronics Beijing Institute of Technology Beijing China
Xu Han: MIIT Key Laboratory for Low‐Dimensional Quantum Structure and Devices, School of Integrated Circuits and Electronics Beijing Institute of Technology Beijing China
Liwei Liu: MIIT Key Laboratory for Low‐Dimensional Quantum Structure and Devices, School of Integrated Circuits and Electronics Beijing Institute of Technology Beijing China
Linfei Li: Department of Chemistry University of Illinois Chicago Chicago Illinois USA
Cesare Grazioli: IOM‐CNR Istituto Officina dei Materiali Trieste Italy
Xu Wu: MIIT Key Laboratory for Low‐Dimensional Quantum Structure and Devices, School of Integrated Circuits and Electronics Beijing Institute of Technology Beijing China
Nan Jiang: Department of Chemistry University of Illinois Chicago Chicago Illinois USA
Yeliang Wang: MIIT Key Laboratory for Low‐Dimensional Quantum Structure and Devices, School of Integrated Circuits and Electronics Beijing Institute of Technology Beijing China

DOI: https://doi.org/10.1002/idm2.12106
Journal volume & issue: Vol. 2, no. 4
pp. 511 – 528

Abstract

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Abstract Imaging biomolecules in real space is crucial for gaining a comprehensive understanding of the properties and functions of biological systems at the most fundamental level. Among the various imaging techniques available for biomolecules and their assembled nanostructures, scanning probe microscopy (SPM) provides a powerful and nondestructive imaging option. SPM is unique in visualizing intrinsically disordered biomolecules at the nanometer scale (e.g., glycans). This review highlights recent achievements in studying biomolecules using SPM technique, focusing on DNA bases, amino acids, proteins, and glycans. The atomic‐level analysis of biomolecules made possible by SPM allows for a more accurate definition of the local structure–property relationship. High‐resolution SPM imaging of single biomolecules offers a new way to study basic processes of life at the molecular level.

Published in Interdisciplinary Materials

ISSN: 2767-4401 (Print); 2767-441X (Online)
Publisher: Wiley
Country of publisher: Australia
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://onlinelibrary.wiley.com/journal/2767441x

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