Nature Communications (Feb 2020)
Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface
- C. Coral Domínguez-Medina,
- Marisol Pérez-Toledo,
- Anna E. Schager,
- Jennifer L. Marshall,
- Charlotte N. Cook,
- Saeeda Bobat,
- Hyea Hwang,
- Byeong Jae Chun,
- Erin Logan,
- Jack A. Bryant,
- Will M. Channell,
- Faye C. Morris,
- Sian E. Jossi,
- Areej Alshayea,
- Amanda E. Rossiter,
- Paul A. Barrow,
- William G. Horsnell,
- Calman A. MacLennan,
- Ian R. Henderson,
- Jeremy H. Lakey,
- James C. Gumbart,
- Constantino López-Macías,
- Vassiliy N. Bavro,
- Adam F. Cunningham
Affiliations
- C. Coral Domínguez-Medina
- Institute of Immunology and Immunotherapy, University of Birmingham
- Marisol Pérez-Toledo
- Institute of Immunology and Immunotherapy, University of Birmingham
- Anna E. Schager
- Institute of Immunology and Immunotherapy, University of Birmingham
- Jennifer L. Marshall
- Institute of Immunology and Immunotherapy, University of Birmingham
- Charlotte N. Cook
- Institute of Immunology and Immunotherapy, University of Birmingham
- Saeeda Bobat
- Institute of Immunology and Immunotherapy, University of Birmingham
- Hyea Hwang
- School of Materials Science and Engineering, Georgia Institute of Technology
- Byeong Jae Chun
- School of Materials Science and Engineering, Georgia Institute of Technology
- Erin Logan
- Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Jack A. Bryant
- Institute of Microbiology and Infection, University of Birmingham
- Will M. Channell
- Institute of Immunology and Immunotherapy, University of Birmingham
- Faye C. Morris
- Institute of Microbiology and Infection, University of Birmingham
- Sian E. Jossi
- Institute of Immunology and Immunotherapy, University of Birmingham
- Areej Alshayea
- Institute of Immunology and Immunotherapy, University of Birmingham
- Amanda E. Rossiter
- Institute of Microbiology and Infection, University of Birmingham
- Paul A. Barrow
- School of Veterinary Medicine and Science, University of Nottingham
- William G. Horsnell
- Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Calman A. MacLennan
- Jenner Institute, Nuffield Department of Medicine, Old Road Campus Research Building, Roosevelt Drive, University of Oxford
- Ian R. Henderson
- Institute of Microbiology and Infection, University of Birmingham
- Jeremy H. Lakey
- Institute for Cell and Molecular Biosciences, University of Newcastle
- James C. Gumbart
- School of Physics, Georgia Institute of Technology
- Constantino López-Macías
- Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre “Siglo XXI” Mexican Institute for Social Security
- Vassiliy N. Bavro
- School of Life Sciences, University of Essex, Wivenhoe Park
- Adam F. Cunningham
- Institute of Immunology and Immunotherapy, University of Birmingham
- DOI
- https://doi.org/10.1038/s41467-020-14655-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
The O-antigen of LPS is known to limit the binding of antibody to bacterial surface antigens. Here the AUs show that the chemical and physical structure of the O-antigen are central factors in limiting the exposure of surface antigens to antibodies during Salmonella infection, thus defining their protective qualities.
