mBio (Oct 2021)

Commensal-Related Changes in the Epidermal Barrier Function Lead to Alterations in the Benzo[ <i>a</i> ]Pyrene Metabolite Profile and Its Distribution in 3D Skin

  • Lisa Lemoine,
  • Dilan Bayrambey,
  • Alexander Roloff,
  • Christoph Hutzler,
  • Andreas Luch,
  • Tewes Tralau

DOI
https://doi.org/10.1128/mBio.01223-21
Journal volume & issue
Vol. 12, no. 5

Abstract

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Exposure to xenobiotics has repeatedly been associated with adverse health effects. While the majority of reported cases relate to direct substance effects, there is increasing evidence that microbiome-dependent metabolism of xenobiotic substances likewise has direct adverse effects on the host.