Nature Communications (Apr 2019)
Autophagy regulates lipid metabolism through selective turnover of NCoR1
- Tetsuya Saito,
- Akiko Kuma,
- Yuki Sugiura,
- Yoshinobu Ichimura,
- Miki Obata,
- Hiroshi Kitamura,
- Shujiro Okuda,
- Hyeon-Cheol Lee,
- Kazutaka Ikeda,
- Yumi Kanegae,
- Izumu Saito,
- Johan Auwerx,
- Hozumi Motohashi,
- Makoto Suematsu,
- Tomoyoshi Soga,
- Takehiko Yokomizo,
- Satoshi Waguri,
- Noboru Mizushima,
- Masaaki Komatsu
Affiliations
- Tetsuya Saito
- Department of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences
- Akiko Kuma
- Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo
- Yuki Sugiura
- Japan Science and Technology Agency, PRESTO
- Yoshinobu Ichimura
- Department of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences
- Miki Obata
- Department of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences
- Hiroshi Kitamura
- Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University
- Shujiro Okuda
- Bioinformatics Laboratory, Niigata University Graduate School of Medical and Dental Sciences
- Hyeon-Cheol Lee
- Department of Biochemistry, Juntendo University Graduate School of Medicine
- Kazutaka Ikeda
- Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS)
- Yumi Kanegae
- Core Research Facilities of Basic Science (Molecular Genetics), Research Center for Medical Science, Jikei University School of Medicine
- Izumu Saito
- Laboratory of Molecular Genetics, Institute of Medical Science, The University of Tokyo
- Johan Auwerx
- Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL)
- Hozumi Motohashi
- Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University
- Makoto Suematsu
- Department of Biochemistry, Keio University School of Medicine
- Tomoyoshi Soga
- Institute for Advanced Biosciences, Keio University
- Takehiko Yokomizo
- Department of Biochemistry, Juntendo University Graduate School of Medicine
- Satoshi Waguri
- Department of Anatomy and Histology, Fukushima Medical University School of Medicine
- Noboru Mizushima
- Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo
- Masaaki Komatsu
- Department of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences
- DOI
- https://doi.org/10.1038/s41467-019-08829-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Defective autophagy has been associated with metabolic disorders. Here Saito et al. show that autophagy promotes the selective degradation of NCoR1, a repressor of lipid metabolism regulator PPARα, in response to starvation, and thus induces the expression of enzymes involved in lipid oxidation and the production of ketone bodies.
