Ultrasound-Assisted Synthesis of 1-N-glycosyl-1H-1,2,3-Triazole Derivatives and their Anti-inflammatory Activity

Abstract

We have been synthesized various glycosyl triazoles from the reaction between glycosyl azide (1) and terminal alkynes (2a-g). The glycopiranosyl 1,2,3-triazoles (3-9) have been obtained in moderate-to-excellent yields (63-99%) through the copper (I)-catalyst 1,3-dipolar cycloaddition reaction at room temperature using ultrasound irradiation. In addition, preliminary anti-inflammatory tests have been performed in the compounds conjugates with benzoheterocycles (3-7) moieties that shown moderate activity

Keywords

• ultrasound
• 1,2,3-triazole
• carbohydrate
• anti-inflammatory