Communications Biology (Jul 2022)
Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program
- Daniel DiCorpo,
- Sheila M. Gaynor,
- Emily M. Russell,
- Kenneth E. Westerman,
- Laura M. Raffield,
- Timothy D. Majarian,
- Peitao Wu,
- Chloé Sarnowski,
- Heather M. Highland,
- Anne Jackson,
- Natalie R. Hasbani,
- Paul S. de Vries,
- Jennifer A. Brody,
- Bertha Hidalgo,
- Xiuqing Guo,
- James A. Perry,
- Jeffrey R. O’Connell,
- Samantha Lent,
- May E. Montasser,
- Brian E. Cade,
- Deepti Jain,
- Heming Wang,
- Ricardo D’Oliveira Albanus,
- Arushi Varshney,
- Lisa R. Yanek,
- Leslie Lange,
- Nicholette D. Palmer,
- Marcio Almeida,
- Juan M. Peralta,
- Stella Aslibekyan,
- Abigail S. Baldridge,
- Alain G. Bertoni,
- Lawrence F. Bielak,
- Chung-Shiuan Chen,
- Yii-Der Ida Chen,
- Won Jung Choi,
- Mark O. Goodarzi,
- James S. Floyd,
- Marguerite R. Irvin,
- Rita R. Kalyani,
- Tanika N. Kelly,
- Seonwook Lee,
- Ching-Ti Liu,
- Douglas Loesch,
- JoAnn E. Manson,
- Ryan L. Minster,
- Take Naseri,
- James S. Pankow,
- Laura J. Rasmussen-Torvik,
- Alexander P. Reiner,
- Muagututi’a Sefuiva Reupena,
- Elizabeth Selvin,
- Jennifer A. Smith,
- Daniel E. Weeks,
- Huichun Xu,
- Jie Yao,
- Wei Zhao,
- Stephen Parker,
- Alvaro Alonso,
- Donna K. Arnett,
- John Blangero,
- Eric Boerwinkle,
- Adolfo Correa,
- L. Adrienne Cupples,
- Joanne E. Curran,
- Ravindranath Duggirala,
- Jiang He,
- Susan R. Heckbert,
- Sharon L. R. Kardia,
- Ryan W. Kim,
- Charles Kooperberg,
- Simin Liu,
- Rasika A. Mathias,
- Stephen T. McGarvey,
- Braxton D. Mitchell,
- Alanna C. Morrison,
- Patricia A. Peyser,
- Bruce M. Psaty,
- Susan Redline,
- Alan R. Shuldiner,
- Kent D. Taylor,
- Ramachandran S. Vasan,
- Karine A. Viaud-Martinez,
- Jose C. Florez,
- James G. Wilson,
- Robert Sladek,
- Stephen S. Rich,
- Jerome I. Rotter,
- Xihong Lin,
- Josée Dupuis,
- James B. Meigs,
- Jennifer Wessel,
- Alisa K. Manning
Affiliations
- Daniel DiCorpo
- Department of Biostatistics, Boston University School of Public Health
- Sheila M. Gaynor
- Department of Biostatistics, Harvard T.H. Chan School of Public Health
- Emily M. Russell
- Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh
- Kenneth E. Westerman
- Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital
- Laura M. Raffield
- Department of Genetics, University of North Carolina
- Timothy D. Majarian
- Metabolism Program, The Broad Institute of MIT and Harvard
- Peitao Wu
- Department of Biostatistics, Boston University School of Public Health
- Chloé Sarnowski
- Department of Biostatistics, Boston University School of Public Health
- Heather M. Highland
- Department of Epidemiology, University of North Carolina at Chapel Hill
- Anne Jackson
- Department of Biostatistics, University of Michigan
- Natalie R. Hasbani
- Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Paul S. de Vries
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Jennifer A. Brody
- Cardiovascular Health Research Unit, University of Washington
- Bertha Hidalgo
- Ryals School of Public Health, University of Alabama at Birmingham
- Xiuqing Guo
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- James A. Perry
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Jeffrey R. O’Connell
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Samantha Lent
- Department of Biostatistics, Boston University School of Public Health
- May E. Montasser
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Brian E. Cade
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Deepti Jain
- Department of Biostatistics, University of Washington
- Heming Wang
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Ricardo D’Oliveira Albanus
- Department of Computational Medicine & Bioinformatics, University of Michigan
- Arushi Varshney
- Department of Computational Medicine & Bioinformatics, University of Michigan
- Lisa R. Yanek
- GeneSTAR Research Program, Johns Hopkins University School of Medicine
- Leslie Lange
- Department of Medicine, Anschutz Medical Campus, University of Colorado Denver
- Nicholette D. Palmer
- Department of Biochemistry, Wake Forest School of Medicine
- Marcio Almeida
- Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Juan M. Peralta
- Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Stella Aslibekyan
- 23andMe
- Abigail S. Baldridge
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Alain G. Bertoni
- Department of Epidemiology & Prevention, Wake Forest School of Medicine, Winston-
- Lawrence F. Bielak
- Department of Epidemiology, School of Public Health, University of Michigan
- Chung-Shiuan Chen
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Yii-Der Ida Chen
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Won Jung Choi
- Psomagen, Inc
- Mark O. Goodarzi
- Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center
- James S. Floyd
- Cardiovascular Health Research Unit, University of Washington
- Marguerite R. Irvin
- Ryals School of Public Health, University of Alabama at Birmingham
- Rita R. Kalyani
- GeneSTAR Research Program, Johns Hopkins University School of Medicine
- Tanika N. Kelly
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Seonwook Lee
- Psomagen, Inc
- Ching-Ti Liu
- Department of Biostatistics, Boston University School of Public Health
- Douglas Loesch
- Program for Personalized and Genomic Medicine, University of Maryland School of Medicine
- JoAnn E. Manson
- Department of Medicine, Harvard Medical School
- Ryan L. Minster
- Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh
- Take Naseri
- Ministry of Health, Government of Samoa
- James S. Pankow
- Division of Epidemiology and Community Health, School of Public Health, University of Minnesota
- Laura J. Rasmussen-Torvik
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Alexander P. Reiner
- Department of Epidemiology, University of Washington
- Muagututi’a Sefuiva Reupena
- Lutia i Puava ‘ae Mapu i Fagalele
- Elizabeth Selvin
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Jennifer A. Smith
- Department of Epidemiology, School of Public Health, University of Michigan
- Daniel E. Weeks
- Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh
- Huichun Xu
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Jie Yao
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Wei Zhao
- Department of Epidemiology, School of Public Health, University of Michigan
- Stephen Parker
- Department of Computational Medicine & Bioinformatics, University of Michigan
- Alvaro Alonso
- Department of Epidemiology, Rollins School of Public Health, Emory University
- Donna K. Arnett
- College of Public Health, University of Kentucky
- John Blangero
- Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Eric Boerwinkle
- Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Adolfo Correa
- Department of Medicine, University of Mississippi Medical Center
- L. Adrienne Cupples
- Department of Biostatistics, Boston University School of Public Health
- Joanne E. Curran
- Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Ravindranath Duggirala
- Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Jiang He
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Susan R. Heckbert
- Cardiovascular Health Research Unit, University of Washington
- Sharon L. R. Kardia
- Department of Epidemiology, School of Public Health, University of Michigan
- Ryan W. Kim
- Psomagen, Inc
- Charles Kooperberg
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Simin Liu
- Center for Global Cardiometabolic Health (CGCH)
- Rasika A. Mathias
- GeneSTAR Research Program, Johns Hopkins University School of Medicine
- Stephen T. McGarvey
- International Health Institute and Department of Epidemiology, Brown University School of Public Health
- Braxton D. Mitchell
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Alanna C. Morrison
- Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Patricia A. Peyser
- Department of Epidemiology, School of Public Health, University of Michigan
- Bruce M. Psaty
- Cardiovascular Health Research Unit, University of Washington
- Susan Redline
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Alan R. Shuldiner
- Program for Personalized and Genomic Medicine, University of Maryland School of Medicine
- Kent D. Taylor
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Ramachandran S. Vasan
- National Heart Lung and Blood Institute and Boston University’s Framingham Heart Study
- Karine A. Viaud-Martinez
- Illumina Laboratory Services, Illumina, Inc
- Jose C. Florez
- Metabolism Program, The Broad Institute of MIT and Harvard
- James G. Wilson
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center
- Robert Sladek
- Department of Human Genetics, McGill University, Montreal
- Stephen S. Rich
- Center for Public Health Genomics, University of Virginia
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Xihong Lin
- Department of Biostatistics, Harvard T.H. Chan School of Public Health
- Josée Dupuis
- Department of Biostatistics, Boston University School of Public Health
- James B. Meigs
- Department of Medicine, Harvard Medical School
- Jennifer Wessel
- Department of Epidemiology, Fairbanks School of Public Health
- Alisa K. Manning
- Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital
- DOI
- https://doi.org/10.1038/s42003-022-03702-4
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 12
Abstract
This study of 23,000 non-diabetic individuals highlights loci associated with fasting glucose and fasting insulin in diverse cohorts with whole genome sequence data.
