Communications Biology (Apr 2022)
High-pressure crystallography shows noble gas intervention into protein-lipid interaction and suggests a model for anaesthetic action
- Igor Melnikov,
- Philipp Orekhov,
- Maksim Rulev,
- Kirill Kovalev,
- Roman Astashkin,
- Dmitriy Bratanov,
- Yury Ryzhykau,
- Taras Balandin,
- Sergei Bukhdruker,
- Ivan Okhrimenko,
- Valentin Borshchevskiy,
- Gleb Bourenkov,
- Christoph Mueller-Dieckmann,
- Peter van der Linden,
- Philippe Carpentier,
- Gordon Leonard,
- Valentin Gordeliy,
- Alexander Popov
Affiliations
- Igor Melnikov
- Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH
- Philipp Orekhov
- Faculty of Biology, Lomonosov Moscow State University
- Maksim Rulev
- Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH
- Kirill Kovalev
- Institut de Biologie Structurale (IBS), Université Grenoble Alpes, CNRS, CEA
- Roman Astashkin
- Institut de Biologie Structurale (IBS), Université Grenoble Alpes, CNRS, CEA
- Dmitriy Bratanov
- Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH
- Yury Ryzhykau
- Research Center for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology
- Taras Balandin
- Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH
- Sergei Bukhdruker
- European Synchrotron Radiation Facility
- Ivan Okhrimenko
- Research Center for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology
- Valentin Borshchevskiy
- Research Center for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology
- Gleb Bourenkov
- European Molecular Biology Laboratory (EMBL), Hamburg Outstation
- Christoph Mueller-Dieckmann
- European Synchrotron Radiation Facility
- Peter van der Linden
- PSCM (Partnership for Soft Condensed Matter), ESRF
- Philippe Carpentier
- European Synchrotron Radiation Facility
- Gordon Leonard
- European Synchrotron Radiation Facility
- Valentin Gordeliy
- Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH
- Alexander Popov
- European Synchrotron Radiation Facility
- DOI
- https://doi.org/10.1038/s42003-022-03233-y
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 12
Abstract
Noble gases are known to interact with proteins and can be good anaesthetics in hyperbaric conditions. This study identifies argon and krypton binding sites on membrane proteins and proposes as a hypothesis that noble gases, by altering protein/lipid contacts, may affect protein function.
