Nature Communications (Mar 2019)

Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins

  • Xeni Miliara,
  • Takashi Tatsuta,
  • Jamie-Lee Berry,
  • Sarah L. Rouse,
  • Kübra Solak,
  • Dror S. Chorev,
  • Di Wu,
  • Carol V. Robinson,
  • Stephen Matthews,
  • Thomas Langer

DOI
https://doi.org/10.1038/s41467-019-09089-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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The Ups/PRELI family mediates intramitochondrial lipid distribution and synthesis by shuttling phospholipids between both mitochondrial membranes. Here the authors combine X-ray crystallography, MD simulations and yeast genetic screens and identify residues that are important for Ups/PRELI lipid specificity and reveal a dual lipid recognition mechanism in Ups/PRELI family members.