Nature Communications (Dec 2017)

RNA degradation by the plant RNA exosome involves both phosphorolytic and hydrolytic activities

  • Natalia Sikorska,
  • Hélène Zuber,
  • Anthony Gobert,
  • Heike Lange,
  • Dominique Gagliardi

DOI
https://doi.org/10.1038/s41467-017-02066-2
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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The yeast and human RNA exosome is structurally related to prokaryotic phosphorylases but degrades RNA only via associated hydrolytic activities. Here the authors show that the RNA exosome of plants, and likely those of a few basal eukaryotes, combines phosphorolytic and hydrolytic activities to degrade RNA.