Elagolix is porphyrogenic and may induce porphyric attacks in patients with the acute hepatic porphyrias

Abstract

Elagolix is an FDA-approved treatment for moderate-to-severe pain associated with endometriosis but has been associated with increased acute porphyric attacks in women with the acute hepatic porphyrias (AHPs). A fluorescence-based screening assay for drug porphyrogenicity in LMH cells indicates that elagolix is porphyrogenic; thus, elagolix should be avoided or used with caution in patients with the AHPs.

Keywords

• Acute hepatic porphyrias
• Elagolix
• Porphyrogenic
• Endometriosis
• OBGYN
• Hepatology