Structural and Functional Indexes of Cardiovascular System and Kidneys Against Insulin Resistance in Patients with Type 2 Diabetes Mellitus and Obesity

Abstract

The article deals with the results of study of structural and functional indexes of the cardiovascular system and kidneys, pancreatic β-cells function, severity of insulin resistance in patients with type 2 diabetes mellitus and obesity against arterial hypertension. In examined patients the significant insulin resistance was detected in preserved and even increased functional activity of pancreatic β-cells, it was detected predominance of concentric hypertrophy in left ventricular myocardium and diastolic dysfunction with the increase in stiffness of left ventricular myocardium, as well as carotid artery intima-media thickness with the high risk for cardiovascular events. Direct correlation was established between the structural and geometric indexes of left ventricular myocardium and diastolic dysfunction and the level of albuminuria, insulin resistance, duration of diabetes mellitus and hypertension, level of systolic blood pressure and glycated haemoglobin, waist circumference in these patients.

Keywords

• type 2 diabetes mellitus
• obesity
• cardiovascular system
• albuminuria