Generation of a control iPS cell line (JUCGRMi005-A) with no abnormalities in Parkinson's disease-related genes

Kei-ichi Ishikawa; Takahiro Shiga; Manabu Funayama; Nobutaka Hattori; Wado Akamatsu

Stem Cell Research (Feb 2024)

Generation of a control iPS cell line (JUCGRMi005-A) with no abnormalities in Parkinson's disease-related genes

Kei-ichi Ishikawa,
Takahiro Shiga,
Manabu Funayama,
Nobutaka Hattori,
Wado Akamatsu

Affiliations

Kei-ichi Ishikawa: Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Department of Research and Development for Organoids, Juntendo University School of Medicine, Tokyo, Japan; Corresponding author.
Takahiro Shiga: Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
Manabu Funayama: Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan
Nobutaka Hattori: Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Department of Research and Development for Organoids, Juntendo University School of Medicine, Tokyo, Japan; Neurodegenerative Disorders Collaborative Laboratory, RIKEN Center for Brain Science, Saitama, Japan
Wado Akamatsu: Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Journal volume & issue: Vol. 74
p. 103271

Abstract

Read online

Appropriate control induced pluripotent stem cells (iPSCs) are essential for studying iPSCs derived from patients with Parkinson’s disease (PD). In this study, we established an iPSC line from a healthy male donor. The iPSCs showed pluripotency, capacity to differentiate into three germ layers, and normal karyotypes. Additionally, we confirmed that the iPSC line did not exhibit any PD-related gene abnormalities. This iPSC line will be useful for PD research.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

About the journal