Therapeutic Potentials of <i>Syzygium fruticosum</i> Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways
Jannatul Nasma Rupa Moni,
Md. Adnan,
Abu Montakim Tareq,
Md. Imtiazul Kabir,
A.S.M. Ali Reza,
Mst. Samima Nasrin,
Kamrul Hasan Chowdhury,
Syed Al Jawad Sayem,
Md Atiar Rahman,
AHM Khurshid Alam,
Seema Binte Alam,
Mahfuz Ahmed Sakib,
Ki Kwang Oh,
Dong Ha Cho,
Raffaele Capasso
Affiliations
Jannatul Nasma Rupa Moni
Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh
Md. Adnan
Department of Bio-Health Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea
Abu Montakim Tareq
Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh
Md. Imtiazul Kabir
Department of Pharmaceutical Science, South Dakota State University, Bookings, SD 57006, USA
A.S.M. Ali Reza
Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh
Mst. Samima Nasrin
Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh
Kamrul Hasan Chowdhury
Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh
Syed Al Jawad Sayem
Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh
Md Atiar Rahman
Department of Biochemistry & Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh
AHM Khurshid Alam
Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh
Seema Binte Alam
Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh
Mahfuz Ahmed Sakib
Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh
Ki Kwang Oh
Department of Bio-Health Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea
Dong Ha Cho
Department of Bio-Health Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea
Raffaele Capasso
Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy
Syzygium fruticosum (SF), a valuable Bangladeshi fruit, is considered an alternative therapeutic agent. Mainly, seeds are used as nutritional phytotherapy to ease physical and mental status by preventing chronic diseases. Here, we scrutinized the S. fruticosum seed’s fundamental importance in traditional medicine by following an integrated approach combining in vivo, in vitro, and in silico studies. The SF was fractionated with different solvents, and the ethyl acetate fraction of SF (EaF-SF) was further studied. Mice treated with EaF-SF (200 and 400 mg/kg) manifested anxiolysis evidenced by higher exploration in elevated plus maze and hole board tests. Similarly, a dose-dependent drop of immobility time in a forced swimming test ensured significant anti-depressant activity. Moreover, higher dose treatment exposed reduced exploratory behaviour resembling decreased movement and prolonged sleeping latency with a quick onset of sleep during the open field and thiopental-induced sleeping tests, respectively. In parallel, EaF-SF significantly (p p S. fruticosum seed is a prospective source of health-promoting effects that can be an excellent candidate for preventing degenerative diseases.