Germanium/niobium/polyetherketoneketone ternary biocomposite with crisscross micro-nano patterns created by femtosecond laser for enhancing bone-bonding and resisting infection

Wu Wei; Quan Yu; Ruixia Yang; Xiuhai Zhang; Weizhou Li; Jun Zhao

Materials & Design (Oct 2023)

Germanium/niobium/polyetherketoneketone ternary biocomposite with crisscross micro-nano patterns created by femtosecond laser for enhancing bone-bonding and resisting infection

Wu Wei,
Quan Yu,
Ruixia Yang,
Xiuhai Zhang,
Weizhou Li,
Jun Zhao

Affiliations

Wu Wei: Department of Orthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China; School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China
Quan Yu: Department of Orthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China
Ruixia Yang: School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China
Xiuhai Zhang: School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China
Weizhou Li: School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China; School of Materials Science and Engineering, Xiamen University of Technology, Xiamen 361024, China; Corresponding authors at: School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China(Weizhou Li).
Jun Zhao: Department of Orthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China; Corresponding authors at: School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China(Weizhou Li).

Journal volume & issue: Vol. 234
p. 112337

Abstract

Read online

Loosening and infection are two main reasons for the failure of orthopedic implants. Bone-bonding strengthens the fixation/stability of implants with host bone that extends its service life. Herein, a germanium (Ge)/niobium (Nb)/polyetherketoneketone (PEKK) ternary composite (GNP) was fabricated by melting blend, and crisscross micro-nano patterns on GNP (GNPF) were created by femtosecond laser. The results displayed compared with PEKK and GNP, GNPF with micro-nano patterns displayed remarkable upgradation in surface properties with higher roughness and hydrophilicity/surface energy, etc. GNPF not only promoted osteoblast differentiation but also encouraged the M2 macrophage polarization in vitro. Moreover, GNPF inhibited the bacteria reproduction in vitro, and resisted infection in vivo owing to the sustained release of Ge ion. Further, GNPF remarkably facilitated bone-formation and bone-bonding by inhibiting fibrous capsules in vivo. The mechanism for enhancements of osteoblast response and M2 macrophage polarization in vitro, and bone-bonding in vivo for GNPF was attributed to the cooperative effect of the micro-nano patterns and sustained release of Ge/Nb ions. Consequently, GNPF with osteogenic, anti-inflammatory, and anti-bacterial functions boosted bone-bonding and resisted infection, thereby displaying a promising potential for construction of segmental bone defects.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

About the journal

Abstract

Keywords