mBio
(Apr 2021)
Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis
Huong Thi Pham,
Wen Shi,
Yuwei Xiang,
Su Yi Foo,
Manuel R. Plan,
Pascal Courtin,
Marie-Pierre Chapot-Chartier,
Eddy J. Smid,
Zhao-Xun Liang,
Esteban Marcellin,
Mark S. Turner
Affiliations
Huong Thi Pham
School of Agriculture and Food Sciences, University of Queensland, Brisbane, Queensland, Australia
Wen Shi
School of Agriculture and Food Sciences, University of Queensland, Brisbane, Queensland, Australia
Yuwei Xiang
School of Agriculture and Food Sciences, University of Queensland, Brisbane, Queensland, Australia
Su Yi Foo
School of Agriculture and Food Sciences, University of Queensland, Brisbane, Queensland, Australia
Manuel R. Plan
Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia
Pascal Courtin
Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France
Marie-Pierre Chapot-Chartier
ORCiD Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France
Eddy J. Smid
Laboratory of Food Microbiology, Wageningen University and Research, Wageningen, The Netherlands
Zhao-Xun Liang
ORCiD School of Biological Sciences, Nanyang Technological University, Singapore
Esteban Marcellin
Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia
Mark S. Turner
ORCiD School of Agriculture and Food Sciences, University of Queensland, Brisbane, Queensland, Australia
DOI
https://doi.org/10.1128/mBio.00324-21
Journal volume & issue
Vol. 12,
no. 2
Abstract
Read online
The bacterial second messenger cyclic di-AMP (c-di-AMP) is a global regulator of potassium homeostasis and compatible solute uptake in many Gram-positive bacteria, making it essential for osmoregulation. The role that c-di-AMP plays in β-lactam resistance, however, is unclear despite being first identified a decade ago.
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