Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation

• Makoto Tanaka,
• Hiroyuki Yamada,
• Satoshi Nishikawa,
• Hiroshi Mori,
• Yasuo Ochi,
• Naoto Horai,
• Minqi Li,
• Norio Amizuka

Affiliations

Makoto Tanaka

Research Promotion, Ono Pharmaceutical Co., Ltd., Shimamoto, Osaka 618-8585, Japan

Hiroyuki Yamada

Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd., Shimamoto, Osaka 618-8585, Japan

Satoshi Nishikawa

Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd., Shimamoto, Osaka 618-8585, Japan

Hiroshi Mori

Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd., Shimamoto, Osaka 618-8585, Japan

Yasuo Ochi

Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd., Shimamoto, Osaka 618-8585, Japan

Naoto Horai

Shin Nippon Biomedical Laboratories, Ltd., Drug Safety Research Laboratories, Miyanoura, Kagoshima 891-1394, Japan

Minqi Li

Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan

Norio Amizuka

Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan