The Effect of Aquae Extract of Aloe vera on Synaptophysin Expression after Spinal Cord Compression in Adult Rats

Abstract

Background: Spinal cord compression is one of causes for disability. Nowadaysto minimize these complication is a goal. Objective: The effect of aquae extract of Aloe vera on motoneuron death and chemical neurotransmitter for cell signaling in paralysed rats. Methods: We used 32 female rats from Razi institute. They were randomized divided to 4 groups: 1- control 2- treated with Aloe vera 3- treated with Aloe vera + spinal cord compression by clips aneurysm 4- control+spinal cord compression by clips aneurysm. Perituneal injection continued for 4 weeks (every day). We used 2.5 mg/kg aquae extract of Aloe vera. Results: Compression hascaused, motoneuron in ventral horn decreases with cavitation. Insecond group these changes are less (p≤ 0.05). Aloe vera increasessynaptophysin in complete and partial model (p≤ 0.05). Conclusion: For the first time Aloe vera has studied for synaptic reaction. It seems the number and percentage of motoneurons increased, as the same as synaptophysin in complete and partial model.

Keywords

• keywords: aloe vera
• spinal cord injury
• synaptophysin