Dietary and physical activity adaptations to alternate day modified fasting: implications for optimal weight loss

Abstract

Abstract Background Alternate day modified fasting (ADMF) is an effective strategy for weight loss in obese adults. Objective The objective of this study was to examine the dietary and physical activity adaptations that occur during short-term ADMF, and to determine how these modulations affect rate of weight loss. Methods Sixteen obese subjects (12 women/4 men) completed a 10-week trial consisting of 3 phases: 1) 2-week control phase, 2) 4-week ADMF controlled feeding phase, and 3) 4-week ADMF self-selected feeding phase. Results Body weight decreased (P r = 0.42, P = 0.01). Dietary fat intake decreased (36% to 33% of kcal, P r = 0.38, P = 0.03). Hunger on the fast day decreased (P Conclusion These findings indicate that obese subjects quickly adapt to ADMF, and that changes in energy/macronutrient intake, hunger, and maintenance of physical activity play a role in influencing rate of weight loss by ADMF.