Indian Journal of Paediatric Dermatology (Jan 2020)

Rare association of juvenile xanthogranuloma and acute lymphoblastic leukemia

  • Palvi Singla,
  • Rima Joshi,
  • Bela J Shah

DOI
https://doi.org/10.4103/ijpd.ijpd_49_19
Journal volume & issue
Vol. 21, no. 3
pp. 209 – 211

Abstract

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Juvenile xanthogranuloma (JXG) is a rare non-Langerhans cell histiocytosis that usually occurs during infancy and early childhood. It is seen in combination with juvenile chronic myelomonocytic leukemia and/or neurofibromatosis type 1. The association with acute lymphoblastic leukemia (ALL) is rarely seen. We present a 2-year-old boy who had this rare combination and presented with multiple tan-orange-colored macules, papules, and nodules over the upper body and distal aspect of lower limbs for 4 months of age. The histologic evaluation and immunohistochemistry analysis resulted in the diagnosis of JXG. Bone marrow biopsy showed lymphoblastosis with marked suppression of erythroid and myeloid cells, suggesting ALL.

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