Identification of first active compounds in drug discovery. how to proceed?

Abstract

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In the quest for the discovery of new therapies, the identification of the initial active molecules is a major challenge. Although significant progress in chemistry and biology has been made in recent years, the process remains difficult. In this mini-review, we will explain the major approaches and experimental methods that can be used to identify these molecules. Two main approaches are described, target-based and phenotypic-based and a focus is made on some high throughput technologies and biophysical methods.

Keywords

• drug discovery
• small organic compounds
• screening methods
• HTS
• biophysics