Haematologica
(Jul 2020)
An international, multicenter study of intravenous bevacizumab for bleeding in hereditary hemorrhagic telangiectasia: the InHIBIT-Bleed study
Hanny Al-Samkari,
Raj S. Kasthuri,
Joseph G. Parambil,
Hasan A. Albitar,
Yahya A. Almodallal,
Carolina Vázquez,
Marcelo M. Serra,
Sophie Dupuis-Girod,
Craig B. Wilsen,
Justin P. McWilliams,
Evan H. Fountain,
James R. Gossage,
Clifford R. Weiss,
Muhammad A. Latif,
Assaf Issachar,
Meir Mei-Zahav,
Mary E. Meek,
Miles Conrad,
Josanna Rodriguez-Lopez,
David J. Kuter,
Vivek N. Iyer
Affiliations
Hanny Al-Samkari
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;
Raj S. Kasthuri
Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;
Joseph G. Parambil
Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA;
Hasan A. Albitar
Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA;
Yahya A. Almodallal
Department of Pediatrics, Mayo Clinic, Rochester, MN, USA;
Carolina Vázquez
Department of Internal Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina;
Marcelo M. Serra
Department of Internal Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina;
Sophie Dupuis-Girod
Centre de Reference pour la maladie de Rendu-Osler, Hospices Civils de Lyon, Lyon, France;
Craig B. Wilsen
Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA;
Justin P. McWilliams
Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA;
Evan H. Fountain
Division of Pulmonary, Critical Care, and Sleep Medicine, Augusta University, Augusta, GA, USA;
James R. Gossage
Division of Pulmonary, Critical Care, and Sleep Medicine, Augusta University, Augusta, GA, USA;
Clifford R. Weiss
Div. of Interventional Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA;
Muhammad A. Latif
Div. of Interventional Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA;
Assaf Issachar
Schneider Children's Medical Center of Israel, Tel Aviv University, Israel;
Meir Mei-Zahav
Schneider Children's Medical Center of Israel, Tel Aviv University, Israel;
Mary E. Meek
Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA;
Miles Conrad
Dept. of Radiology, University of California San Francisco Medical Center, San Francisco, CA, USA;
Josanna Rodriguez-Lopez
Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, USA;
David J. Kuter
Division of Hematology, Massachusetts General Hospital, Boston, MA, USA;
Vivek N. Iyer
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA
DOI
https://doi.org/10.3324/haematol.2020.261859
Journal volume & issue
Vol. 106,
no. 8
Abstract
Read online
Hereditary hemorrhagic telangiectasia (HHT, Osler-Weber-Rendu disease) is a rare multisystem vascular disorder causing chronic gastrointestinal bleeding, epistaxis, and severe anemia. Bevacizumab, an anti-vascular endothelial growth factor antibody, may be effective to treat bleeding in HHT. This international, multicenter, retrospective study evaluated the use of systemic bevacizumab to treat HHT-associated bleeding and anemia at 12 HHT treatment centers. Hemoglobin, epistaxis severity score, red cell units transfused, and intravenous iron infusions before and after treatment were evaluated using paired means testing and mixed-effects linear models. 238 HHT patients received bevacizumab for a median of 12 (range, 1-96) months. Compared with pretreatment, bevacizumab increased mean hemoglobin by 3.2 g/dL (95% CI, 2.9-3.5 g/dL) [mean hemoglobin 8.6 (8.5, 8.8) g/dL versus 11.8 (11.5, 12.1) g/dL, p
Published in Haematologica
ISSN
0390-6078 (Print)
1592-8721 (Online)
Publisher
Ferrata Storti Foundation
Country of publisher
Italy
LCC subjects
Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website
http://www.haematologica.org
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