Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response

Jonathan D. Herman; Chuangqi Wang; Carolin Loos; Hyunah Yoon; Johanna Rivera; M. Eugenia Dieterle; Denise Haslwanter; Rohit K. Jangra; Robert H. Bortz; Katharine J. Bar; Boris Julg; Kartik Chandran; Douglas Lauffenburger; Liise-anne Pirofski; Galit Alter

doi:10.1038/s41467-021-27201-y

Nature Communications (Nov 2021)

Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response

Jonathan D. Herman,
Chuangqi Wang,
Carolin Loos,
Hyunah Yoon,
Johanna Rivera,
M. Eugenia Dieterle,
Denise Haslwanter,
Rohit K. Jangra,
Robert H. Bortz,
Katharine J. Bar,
Boris Julg,
Kartik Chandran,
Douglas Lauffenburger,
Liise-anne Pirofski,
Galit Alter

Affiliations

Jonathan D. Herman: Ragon Institute of MGH, MIT, and Harvard
Chuangqi Wang: Department of Biological Engineering, Massachusetts Institute of Technology
Carolin Loos: Ragon Institute of MGH, MIT, and Harvard
Hyunah Yoon: Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center
Johanna Rivera: Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center
M. Eugenia Dieterle: Department of Microbiology and Immunology, Albert Einstein College of Medicine
Denise Haslwanter: Department of Microbiology and Immunology, Albert Einstein College of Medicine
Rohit K. Jangra: Department of Microbiology and Immunology, Louisiana State University Health Science Center-Shreveport
Robert H. Bortz: Department of Microbiology and Immunology, Albert Einstein College of Medicine
Katharine J. Bar: Department of Medicine, University of Pennsylvania
Boris Julg: Ragon Institute of MGH, MIT, and Harvard
Kartik Chandran: Department of Microbiology and Immunology, Albert Einstein College of Medicine
Douglas Lauffenburger: Department of Biological Engineering, Massachusetts Institute of Technology
Liise-anne Pirofski: Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center
Galit Alter: Ragon Institute of MGH, MIT, and Harvard

DOI: https://doi.org/10.1038/s41467-021-27201-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Convalescent plasma (CP) has been trialed as a therapy for SARS-CoV-2 symptoms, but its heterogenous nature precludes uniform outcomes. Here the authors perform deep profiling of CP, as well as plasma of CP recipients before and after transfer, to find CP-mediated, spike/nucleocapsid-focused modulations of humoral responses in the recipient.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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