Nature Communications (Feb 2022)
HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources
- Alizee Lebeau,
- Diane Bruyere,
- Patrick Roncarati,
- Paul Peixoto,
- Eric Hervouet,
- Gael Cobraiville,
- Bernard Taminiau,
- Murielle Masson,
- Carmen Gallego,
- Gabriel Mazzucchelli,
- Nicolas Smargiasso,
- Maximilien Fleron,
- Dominique Baiwir,
- Elodie Hendrick,
- Charlotte Pilard,
- Thomas Lerho,
- Celia Reynders,
- Marie Ancion,
- Roland Greimers,
- Jean-Claude Twizere,
- Georges Daube,
- Geraldine Schlecht-Louf,
- Françoise Bachelerie,
- Jean-Damien Combes,
- Pierrette Melin,
- Marianne Fillet,
- Philippe Delvenne,
- Pascale Hubert,
- Michael Herfs
Affiliations
- Alizee Lebeau
- Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege
- Diane Bruyere
- Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege
- Patrick Roncarati
- Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege
- Paul Peixoto
- INSERM, EFS BFC, UMR 1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, University of Bourgogne Franche-Comté
- Eric Hervouet
- INSERM, EFS BFC, UMR 1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, University of Bourgogne Franche-Comté
- Gael Cobraiville
- Laboratory for the Analysis of Medicines, Center for Interdisciplinary Research on Medicines (CIRM), University of Liege
- Bernard Taminiau
- Department of Food Sciences-Microbiology, Fundamental and Applied Research for Animals and Health (FARAH), Faculty of Veterinary Medicine, University of Liege
- Murielle Masson
- Ecole Supérieure de Biotechnologie Strasbourg, UMR 7242, CNRS, University of Strasbourg
- Carmen Gallego
- INSERM UMR 996, Inflammation Microbiome and Immunosurveillance, University of Paris-Saclay
- Gabriel Mazzucchelli
- Laboratory of Mass Spectrometry, Department of Chemistry, University of Liege
- Nicolas Smargiasso
- Laboratory of Mass Spectrometry, Department of Chemistry, University of Liege
- Maximilien Fleron
- Laboratory of Mass Spectrometry, Department of Chemistry, University of Liege
- Dominique Baiwir
- Laboratory of Mass Spectrometry, Department of Chemistry, University of Liege
- Elodie Hendrick
- Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege
- Charlotte Pilard
- Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege
- Thomas Lerho
- Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege
- Celia Reynders
- Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege
- Marie Ancion
- Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege
- Roland Greimers
- Department of Pathology, University Hospital Center of Liege
- Jean-Claude Twizere
- Laboratory of Signaling and Protein Interactions, GIGA-Molecular Biology of Diseases, University of Liege
- Georges Daube
- Department of Food Sciences-Microbiology, Fundamental and Applied Research for Animals and Health (FARAH), Faculty of Veterinary Medicine, University of Liege
- Geraldine Schlecht-Louf
- INSERM UMR 996, Inflammation Microbiome and Immunosurveillance, University of Paris-Saclay
- Françoise Bachelerie
- INSERM UMR 996, Inflammation Microbiome and Immunosurveillance, University of Paris-Saclay
- Jean-Damien Combes
- Infections and Cancer Epidemiology Group, International Agency for Research on Cancer, World Health Organization
- Pierrette Melin
- Department of Clinical Microbiology, University Hospital Center of Liege
- Marianne Fillet
- Laboratory for the Analysis of Medicines, Center for Interdisciplinary Research on Medicines (CIRM), University of Liege
- Philippe Delvenne
- Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege
- Pascale Hubert
- Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege
- Michael Herfs
- Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege
- DOI
- https://doi.org/10.1038/s41467-022-28724-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Here, the authors show that HPV infection leads to downregulation of host mucosal innate peptides, which are in turn used by predominant Lactobacillus species as amino acid source, promoting ultimately an imbalance in the vaginal flora.
