Communications Biology (Sep 2022)
Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development
- Daniel Sobral,
- Marta Martins,
- Shannon Kaplan,
- Mahdi Golkaram,
- Michael Salmans,
- Nafeesa Khan,
- Raakhee Vijayaraghavan,
- Sandra Casimiro,
- Afonso Fernandes,
- Paula Borralho,
- Cristina Ferreira,
- Rui Pinto,
- Catarina Abreu,
- Ana Lúcia Costa,
- Shile Zhang,
- Traci Pawlowski,
- Jim Godsey,
- André Mansinho,
- Daniela Macedo,
- Soraia Lobo-Martins,
- Pedro Filipe,
- Rui Esteves,
- João Coutinho,
- Paulo Matos Costa,
- Afonso Ramires,
- Fernando Aldeia,
- António Quintela,
- Alex So,
- Li Liu,
- Ana Rita Grosso,
- Luis Costa
Affiliations
- Daniel Sobral
- Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa
- Marta Martins
- Instituto de Medicina Molecular- João Lobo Antunes, Faculdade de Medicina de Lisboa, Avenida Professor Egas Moniz
- Shannon Kaplan
- Illumina Inc.
- Mahdi Golkaram
- Illumina Inc.
- Michael Salmans
- Illumina Inc.
- Nafeesa Khan
- Illumina Inc.
- Raakhee Vijayaraghavan
- Illumina Inc.
- Sandra Casimiro
- Instituto de Medicina Molecular- João Lobo Antunes, Faculdade de Medicina de Lisboa, Avenida Professor Egas Moniz
- Afonso Fernandes
- Instituto de Medicina Molecular- João Lobo Antunes, Faculdade de Medicina de Lisboa, Avenida Professor Egas Moniz
- Paula Borralho
- Instituto de Medicina Molecular- João Lobo Antunes, Faculdade de Medicina de Lisboa, Avenida Professor Egas Moniz
- Cristina Ferreira
- Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria
- Rui Pinto
- Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa
- Catarina Abreu
- Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria
- Ana Lúcia Costa
- Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria
- Shile Zhang
- Illumina Inc.
- Traci Pawlowski
- Illumina Inc.
- Jim Godsey
- Illumina Inc.
- André Mansinho
- Instituto de Medicina Molecular- João Lobo Antunes, Faculdade de Medicina de Lisboa, Avenida Professor Egas Moniz
- Daniela Macedo
- Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria
- Soraia Lobo-Martins
- Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria
- Pedro Filipe
- Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria
- Rui Esteves
- Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria
- João Coutinho
- Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria
- Paulo Matos Costa
- Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria
- Afonso Ramires
- Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria
- Fernando Aldeia
- Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria
- António Quintela
- Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria
- Alex So
- Illumina Inc.
- Li Liu
- Illumina Inc.
- Ana Rita Grosso
- Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa
- Luis Costa
- Instituto de Medicina Molecular- João Lobo Antunes, Faculdade de Medicina de Lisboa, Avenida Professor Egas Moniz
- DOI
- https://doi.org/10.1038/s42003-022-03884-x
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 14
Abstract
The genetic and microenvironmental heterogeneity of colorectal cancer is analyzed using a prospective biobank of primary and metastatic tumor tissues to highlight features of intra-tumoral heterogeneity that favor tumor progression and metastasis.
