Nature Communications (Sep 2017)
Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis
- Beben Benyamin,
- Ji He,
- Qiongyi Zhao,
- Jacob Gratten,
- Fleur Garton,
- Paul J. Leo,
- Zhijun Liu,
- Marie Mangelsdorf,
- Ammar Al-Chalabi,
- Lisa Anderson,
- Timothy J. Butler,
- Lu Chen,
- Xiang-Ding Chen,
- Katie Cremin,
- Hong-Weng Deng,
- Matthew Devine,
- Janette Edson,
- Jennifer A. Fifita,
- Sarah Furlong,
- Ying-Ying Han,
- Jessica Harris,
- Anjali K. Henders,
- Rosalind L. Jeffree,
- Zi-Bing Jin,
- Zhongshan Li,
- Ting Li,
- Mengmeng Li,
- Yong Lin,
- Xiaolu Liu,
- Mhairi Marshall,
- Emily P. McCann,
- Bryan J. Mowry,
- Shyuan T. Ngo,
- Roger Pamphlett,
- Shu Ran,
- David C. Reutens,
- Dominic B. Rowe,
- Perminder Sachdev,
- Sonia Shah,
- Sharon Song,
- Li-Jun Tan,
- Lu Tang,
- Leonard H. van den Berg,
- Wouter van Rheenen,
- Jan H. Veldink,
- Robyn H. Wallace,
- Lawrie Wheeler,
- Kelly L. Williams,
- Jinyu Wu,
- Xin Wu,
- Jian Yang,
- Weihua Yue,
- Zong-Hong Zhang,
- Dai Zhang,
- Peter G. Noakes,
- Ian P. Blair,
- Robert D. Henderson,
- Pamela A. McCombe,
- Peter M. Visscher,
- Huji Xu,
- Perry F. Bartlett,
- Matthew A. Brown,
- Naomi R. Wray,
- Dongsheng Fan
Affiliations
- Beben Benyamin
- Queensland Brain Institute, The University of Queensland
- Ji He
- Department of Neurology, Peking University, Third Hospital
- Qiongyi Zhao
- Queensland Brain Institute, The University of Queensland
- Jacob Gratten
- Queensland Brain Institute, The University of Queensland
- Fleur Garton
- Queensland Brain Institute, The University of Queensland
- Paul J. Leo
- University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
- Zhijun Liu
- Queensland Brain Institute, The University of Queensland
- Marie Mangelsdorf
- Queensland Brain Institute, The University of Queensland
- Ammar Al-Chalabi
- Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London
- Lisa Anderson
- University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
- Timothy J. Butler
- Queensland Brain Institute, The University of Queensland
- Lu Chen
- Department of Neurology, Peking University, Third Hospital
- Xiang-Ding Chen
- Laboratory of Molecular and Statistical Genetics and State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University
- Katie Cremin
- University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
- Hong-Weng Deng
- Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Center for Bioinformatics and Genomics, Tulane University
- Matthew Devine
- Department of Neurology, Royal Brisbane & Women’s Hospital
- Janette Edson
- Queensland Brain Institute, The University of Queensland
- Jennifer A. Fifita
- Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University
- Sarah Furlong
- Queensland Brain Institute, The University of Queensland
- Ying-Ying Han
- Center of System Biomedical Sciences, University of Shanghai for Science and Technology
- Jessica Harris
- University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
- Anjali K. Henders
- Queensland Brain Institute, The University of Queensland
- Rosalind L. Jeffree
- Kenneth G. Jamieson Department of Neurosurgery, Royal Brisbane & Women’s Hospital
- Zi-Bing Jin
- Division of Ophthalmic Genetics, Laboratory for Stem Cell and Retinal Regeneration, The Eye Hospital of Wenzhou Medical University
- Zhongshan Li
- Institute of Genomic Medicine, Wenzhou Medical University
- Ting Li
- Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medical University
- Mengmeng Li
- Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medical University
- Yong Lin
- Center of System Biomedical Sciences, University of Shanghai for Science and Technology
- Xiaolu Liu
- Department of Neurology, Peking University, Third Hospital
- Mhairi Marshall
- University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
- Emily P. McCann
- Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University
- Bryan J. Mowry
- Queensland Brain Institute, The University of Queensland
- Shyuan T. Ngo
- Queensland Brain Institute, The University of Queensland
- Roger Pamphlett
- Stacey MND Laboratory, Discipline of Pathology, Brain and Mind Centre, The University of Sydney
- Shu Ran
- Center of System Biomedical Sciences, University of Shanghai for Science and Technology
- David C. Reutens
- The Centre for Advanced Imaging, The University of Queensland
- Dominic B. Rowe
- Department of Medicine, Faculty of Medicine and Health Sciences, Multidisciplinary Motor Neurone Disease Clinic, Macquarie University
- Perminder Sachdev
- Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, The University of New South Wales
- Sonia Shah
- Queensland Brain Institute, The University of Queensland
- Sharon Song
- University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
- Li-Jun Tan
- Laboratory of Molecular and Statistical Genetics and State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University
- Lu Tang
- Department of Neurology, Peking University, Third Hospital
- Leonard H. van den Berg
- Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Wouter van Rheenen
- Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Jan H. Veldink
- Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Robyn H. Wallace
- Queensland Brain Institute, The University of Queensland
- Lawrie Wheeler
- University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
- Kelly L. Williams
- Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University
- Jinyu Wu
- Institute of Genomic Medicine, Wenzhou Medical University
- Xin Wu
- Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medical University
- Jian Yang
- Queensland Brain Institute, The University of Queensland
- Weihua Yue
- Institute of Mental Health, The Sixth Hospital, Peking University
- Zong-Hong Zhang
- Queensland Brain Institute, The University of Queensland
- Dai Zhang
- Institute of Mental Health, The Sixth Hospital, Peking University
- Peter G. Noakes
- Department of Neurology, Royal Brisbane & Women’s Hospital
- Ian P. Blair
- Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University
- Robert D. Henderson
- Queensland Brain Institute, The University of Queensland
- Pamela A. McCombe
- Department of Neurology, Royal Brisbane & Women’s Hospital
- Peter M. Visscher
- Queensland Brain Institute, The University of Queensland
- Huji Xu
- Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medical University
- Perry F. Bartlett
- Queensland Brain Institute, The University of Queensland
- Matthew A. Brown
- University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
- Naomi R. Wray
- Queensland Brain Institute, The University of Queensland
- Dongsheng Fan
- Department of Neurology, Peking University, Third Hospital
- DOI
- https://doi.org/10.1038/s41467-017-00471-1
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 7
Abstract
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease. Here, Wray and colleagues identify association of the GPX3-TNIP1 locus with ALS using cross-ethnic meta-analyses.
