Journal of Medical Sciences and Health (Oct 2019)

Coenzyme Q 10 Abrogates Flutamide-induced Hepatotoxicity in Albino Rats

  • Elias Adikwu,
  • Nelson Clemente Ebinyo,
  • Harold Aagbadabina

Journal volume & issue
Vol. 5, no. 2
pp. 1 – 8

Abstract

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Aim: The efficacy and therapeutic benefit of flutamide (FLU) can be clinically limited by the occurrence of hepatotoxicity which may progress to liver failure. This study, therefore, evaluated the protective effect of coenzyme Q 10 (COQ 10) against FLU-induced liver toxicity in albino rats. Objectives: The objectives of this study were to explore and grade the severity of IA in relation to academic performance among medical undergraduates. Materials and Methods: Forty-five adult albino rats of average weight 200–250 g were randomized into groups and treated intraperitoneally with COQ 10; 50 mg/kg + FLU 200 mg/kg, COQ 10; 100 mg/kg + FLU 200 mg/kg and COQ 10; and 200 mg/kg + FLU 200 daily for 7 days. On the 8th day, rats were sacrificed, serum was extracted from blood and liver was excised and evaluated for aspartate aminotransferase (AST), alanine aminotransferase(ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), total bilirubin (TB), and conjugated bilirubin (CB). Liver was evaluated for oxidative stress markers and pathologic changes. Results: Serum and liver AST, ALT, ALP, AST, GGT, LDH, TB, and CB levels were significantly (P < 0.001) increased in FLU-treated rats when compared to placebo control. Liver superoxide dismutase, catalase, glutathione, and glutathione peroxidase were decreased, whereas malondialdehyde levels were increased significantly (P < 0.001) in FLU-treated rats when compared to placebo control. The liver of FLU-treated rats showed hepatocyte necrosis. However, FLU-induced liver toxicity was significantly abrogated in a dose-dependent manner in COQ 10; 50 mg/kg (P < 0.05), COQ 10; 100 mg/kg (P < 0.01); and COQ 10; 200 mg/kg (P < 0.001) pre-treated rats when compared to FLU-treated rats. Conclusions: This study showed that COQ 10 abrogates FLU-induced hepatotoxicity in albino rats in a dose- dependent manner. It may have clinical application in hepatotoxicity associated with FLU.

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