Nature Communications (Sep 2020)
Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS
- Xue Wu,
- Cristina M. Niculite,
- Mihai Bogdan Preda,
- Annalisa Rossi,
- Toma Tebaldi,
- Elena Butoi,
- Mattie K. White,
- Oana M. Tudoran,
- Daniela N. Petrusca,
- Amber S. Jannasch,
- William P. Bone,
- Xingyue Zong,
- Fang Fang,
- Alexandrina Burlacu,
- Michelle T. Paulsen,
- Brad A. Hancock,
- George E. Sandusky,
- Sumegha Mitra,
- Melissa L. Fishel,
- Aaron Buechlein,
- Cristina Ivan,
- Spyros Oikonomopoulos,
- Myriam Gorospe,
- Amber Mosley,
- Milan Radovich,
- Utpal P. Davé,
- Jiannis Ragoussis,
- Kenneth P. Nephew,
- Bernard Mari,
- Alan McIntyre,
- Heiko Konig,
- Mats Ljungman,
- Diana L. Cousminer,
- Paolo Macchi,
- Mircea Ivan
Affiliations
- Xue Wu
- Department of Microbiology and Immunology, Indiana University School of Medicine
- Cristina M. Niculite
- Department of Medicine, Indiana University School of Medicine
- Mihai Bogdan Preda
- Institute of Cellular Biology and Pathology “Nicolae Simionescu”
- Annalisa Rossi
- Laboratory of Molecular and Cellular Neurobiology, Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento
- Toma Tebaldi
- Laboratory of Translational Genomics, Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento
- Elena Butoi
- Institute of Cellular Biology and Pathology “Nicolae Simionescu”
- Mattie K. White
- Department of Medicine, Indiana University School of Medicine
- Oana M. Tudoran
- The Oncology Institute “Prof Dr. Ion Chiricuta”
- Daniela N. Petrusca
- Department of Medicine, Indiana University School of Medicine
- Amber S. Jannasch
- Metabolite Profiling Facility, Bindley Bioscience Center, Purdue University
- William P. Bone
- Department of Genetics, Department of Systems Pharmacology and Translational Therapeutics, Institute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania
- Xingyue Zong
- Department of Cellular and Integrative Physiology, Indiana University School of Medicine
- Fang Fang
- Department of Cellular and Integrative Physiology, Indiana University School of Medicine
- Alexandrina Burlacu
- Institute of Cellular Biology and Pathology “Nicolae Simionescu”
- Michelle T. Paulsen
- Departments of Radiation Oncology and Environmental Health Sciences, Center for RNA Biomedicine, University of Michigan
- Brad A. Hancock
- Department of Surgery, Indiana University School of Medicine
- George E. Sandusky
- Department of Pathology and Laboratory Medicine, Indiana University School of Medicine
- Sumegha Mitra
- Melvin and Bren Simon Cancer Center, Indiana University
- Melissa L. Fishel
- Melvin and Bren Simon Cancer Center, Indiana University
- Aaron Buechlein
- Indiana University Center for Genomics and Bioinformatics
- Cristina Ivan
- Center for RNA Interference and Non-coding RNAs, The University of Texas MD Anderson Cancer Center
- Spyros Oikonomopoulos
- Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, McGill University
- Myriam Gorospe
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Amber Mosley
- Department of Biochemistry and Molecular Biology, Indiana University School of Medicine
- Milan Radovich
- Departments of Radiation Oncology and Environmental Health Sciences, Center for RNA Biomedicine, University of Michigan
- Utpal P. Davé
- Department of Microbiology and Immunology, Indiana University School of Medicine
- Jiannis Ragoussis
- Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, McGill University
- Kenneth P. Nephew
- Department of Cellular and Integrative Physiology, Indiana University School of Medicine
- Bernard Mari
- CNRS, IPMC, FHU-OncoAge, Université Côte d’Azur
- Alan McIntyre
- Rogel Cancer Center, University of Michigan
- Heiko Konig
- Department of Medicine, Indiana University School of Medicine
- Mats Ljungman
- Departments of Radiation Oncology and Environmental Health Sciences, Center for RNA Biomedicine, University of Michigan
- Diana L. Cousminer
- Division of Human Genetics, Department of Pediatrics, The Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania
- Paolo Macchi
- Laboratory of Molecular and Cellular Neurobiology, Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento
- Mircea Ivan
- Department of Microbiology and Immunology, Indiana University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-18411-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Noncoding transcripts contribute to the adaptation of cellular processes to oxygen levels. Here the authors characterize a hypoxia responsive lncRNA lincNORS and show that it has a role in cellular sterol homeostasis.
