Clinical Ophthalmology (Jul 2022)
Early Ophthalmological Manifestations of Acute Myeloid Leukemia: Current Perspectives
Abstract
Nasrine Anais El Salloukh,1 Dany G Hage,2 Anna Z Bashshur,1 Wajiha Jurdi Kheir1 1Ophthalmology Department, American University of Beirut Medical Center, Beirut, Lebanon; 2Tulane University School of Medicine, New Orleans, LA, USACorrespondence: Wajiha Jurdi Kheir, Department of Ophthalmology, American University of Beirut Medical Center, Cairo Street, Beirut, Lebanon, Tel +961-1-350000, Fax +961-1-370837, Email [email protected]: Acute myeloid leukemia (AML) is a hematological malignancy affecting different organ systems including the eye. The purpose of this review is to present and evaluate the medical literature regarding the early ophthalmological manifestations of acute myeloid leukemia. AML affects the ocular system through direct infiltration of tissues, secondary to hematological abnormalities, or in the form of chloroma or myeloid sarcoma in the brain or orbit consequently leading to a variety of manifestations depending on the ocular tissue involved. It is imperative for ophthalmologists to be aware of the early ophthalmological manifestations of AML which will allow for earlier diagnosis and treatment of this life-threatening disease.Keywords: ocular involvement, myeloblastoma, chloroma, myeloid sarcoma, ocular granulocytic sarcoma, leukemic infiltration
