Radiometal-Labeled Chitosan Microspheres as Transarterial Radioembolization Agents against Hepatocellular Carcinoma

Hui-Wen Chan; Yi-Hsuan Lo; Deng-Yuan Chang; Jia-Je Li; Wen-Yi Chang; Chih-Hao Chen; Chih-Hsien Chang; Chuan-Lin Chen; Hsin-Ell Wang; Ren-Shyan Liu; Chun-Yi Wu

doi:10.3390/gels8030180

Gels (Mar 2022)

Radiometal-Labeled Chitosan Microspheres as Transarterial Radioembolization Agents against Hepatocellular Carcinoma

Hui-Wen Chan,
Yi-Hsuan Lo,
Deng-Yuan Chang,
Jia-Je Li,
Wen-Yi Chang,
Chih-Hao Chen,
Chih-Hsien Chang,
Chuan-Lin Chen,
Hsin-Ell Wang,
Ren-Shyan Liu,
Chun-Yi Wu

Affiliations

Hui-Wen Chan: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan
Yi-Hsuan Lo: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan
Deng-Yuan Chang: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan
Jia-Je Li: KeMyth Biotechnology Corporation, NHRI Incubation Center, National Health Research Institutes, Miaoli 350, Taiwan
Wen-Yi Chang: Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan
Chih-Hao Chen: Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan
Chih-Hsien Chang: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan
Chuan-Lin Chen: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan
Hsin-Ell Wang: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan
Ren-Shyan Liu: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan
Chun-Yi Wu: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan

DOI: https://doi.org/10.3390/gels8030180
Journal volume & issue: Vol. 8, no. 3
p. 180

Abstract

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Transarterial radioembolization (TARE) is an emerging treatment for patients with unresectable hepatocellular carcinoma (HCC). This study successfully developed radiometal-labeled chitosan microspheres (111In/177Lu-DTPA-CMS) with a diameter of 36.5 ± 5.3 μm for TARE. The radiochemical yields of 111In/177Lu-DTPA-CMS were greater than 90% with high radiochemical purities (>98%). Most of the 111In/177Lu-DTPA-CMS were retained in the hepatoma and liver at 1 h after intraarterial (i.a.) administration. Except for liver accumulation, radioactivity in each normal organ was less than 1% of the injected radioactivity (%IA) at 72 h after injection. At 10 days after injection of 177Lu-DTPA-CMS (18.6 ± 1.3 MBq), the size of the hepatoma was significantly reduced by around 81%, while that of the rats in the control group continued to grow. This study demonstrated the effectiveness of 177Lu-DTPA-CMS in the treatment of N1-S1 hepatoma. 111In/177Lu-DTPA-CMS have the potential to be a superior theranostic pair for the treatment of clinical hepatoma.

Published in Gels

ISSN: 2310-2861 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Inorganic chemistry; Science: Chemistry: General. Including alchemy
Website: http://www.mdpi.com/journal/gels

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