Effect of insulin therapy and obesity on colon adenoma and advanced adenoma among type II diabetes mellitus population

Abstract

Insulin is a debatable risk factor for colon adenoma (Ad) among type II diabetes mellitus (DM II) patients. Obesity is an important confounding variable. The study involved chart review of DM II patients undergoing screening colonoscopy. Study population was divided into obese [body mass index (BMI)≥30] and nonobese (BMI<30) groups which were further divided into insulin and non-insulin subgroup. Colonoscopy and pathology reports were used to calculate Ad detection rate (ADR) and AAd detection rate (AADR). A total of 538 subjects satisfied the inclusion and exclusion criteria. The study population composed of 52.8% obese and 47.2% non-obese subjects. Obese group had 28.9% insulin and 71.1% non-insulin subjects. Non-obese group composed of 29.9% insulin and 70.1% non-insulin subjects. ADR for non-obese insulin and non-insulin subgroup was 31.6% and 37.1% respectively. AADR for non-obese insulin and non-insulin subgroup was 13.2% and 11.2% respectively. ADR for obese insulin and non-insulin subgroup was 41.5% and 34.2% respectively. AADR for obese insulin and non-insulin subgroup was 15.9% and 16.3% respectively. Insulin exposure lacked statistically significant association with ADR or AADR among obese and non-obese DM II subjects.

Keywords

• Adenoma
• Advanced adenoma
• Diabetes Mellitus type II
• Obesity, Insulin