Nature Communications (Jan 2016)
Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
- Feimeng Zheng,
- Caifeng Yue,
- Guohui Li,
- Bin He,
- Wei Cheng,
- Xi Wang,
- Min Yan,
- Zijie Long,
- Wanshou Qiu,
- Zhongyu Yuan,
- Jie Xu,
- Bing Liu,
- Qian Shi,
- Eric W.-F. Lam,
- Mien-Chie Hung,
- Quentin Liu
Affiliations
- Feimeng Zheng
- Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou
- Caifeng Yue
- Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou
- Guohui Li
- State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Bin He
- Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou
- Wei Cheng
- Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou
- Xi Wang
- Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou
- Min Yan
- Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou
- Zijie Long
- The Third Affiliated Hospital, Sun Yat-Sen University
- Wanshou Qiu
- The Third Affiliated Hospital, Sun Yat-Sen University
- Zhongyu Yuan
- Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou
- Jie Xu
- Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou
- Bing Liu
- Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou
- Qian Shi
- Cancer Hospital/Cancer Institute, College of Life Sciences and Institutes of Biomedical Sciences, Fudan University
- Eric W.-F. Lam
- Department of Surgery and Cancer, Imperial College London
- Mien-Chie Hung
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Quentin Liu
- Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou
- DOI
- https://doi.org/10.1038/ncomms10180
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 17
Abstract
Aurora kinase A is a mitotic kinase that facilitates G2/M events. Here the authors show that in breast cancer cells Aurora kinase A has a kinase-independent function in the nucleus by activating the MYC promoter in cooperation with hnRNP K, enhancing the breast cancer stem cell phenotype.
