Successful monotherapy with autologous formalin‐fixed tumor vaccine for a Stage IV uterine cancer patient who rejected rational chemotherapy and immune checkpoint inhibitor treatment

Abstract

Key Clinical Message To overcome patient‐initiated treatment refusal because of fear of experiencing severe negative adverse events, mild immunotherapy using a cancer vaccine such as the autologous formalin‐fixed tumor vaccine should be considered. Abstract A patient who refused chemotherapy and immune checkpoint inhibitor treatment for Stage IV uterine cancer after displaying circulating tumor cells and high microsatellite instability received monotherapy with autologous formalin‐fixed tumor vaccine (AFTV). Following treatment, we observed regression of multiple lung metastases, suggesting that AFTV is an attractive treatment option.

Keywords

• cancer vaccine
• immunotherapy
• monotherapy
• uterine cancer