Rejuvenating the immune system

Abstract

Rejuvenation of elementary immune system components has emerged as a promising strategy to deal with increased susceptibility to infections, cancers, autoimmune disorders, and low efficacy to vaccines, frequently accompanying aging. In this context, the thymus has gained significant attention. A recent study by Santamaria et al. reveals that the receptor activator of nuclear factor‐κB (RANK)–RANK ligand (RANKL) axis is altered during age related thymic involution, compromising immune responses. Based on their findings, authors propose exogenous RANKL administration as a therapeutic strategy to reinvigorate thymic function and improve T‐cell immunity during aging.

Keywords

• aging
• immune cells
• RANKL
• rejuvenation
• thymus