Nature Communications (Jan 2017)
Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity
- Julie Salomon,
- Cécile Gaston,
- Jérémy Magescas,
- Boris Duvauchelle,
- Danielle Canioni,
- Lucie Sengmanivong,
- Adeline Mayeux,
- Grégoire Michaux,
- Florence Campeotto,
- Julie Lemale,
- Jérôme Viala,
- Françoise Poirier,
- Nicolas Minc,
- Jacques Schmitz,
- Nicole Brousse,
- Benoit Ladoux,
- Olivier Goulet,
- Delphine Delacour
Affiliations
- Julie Salomon
- Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University
- Cécile Gaston
- Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University
- Jérémy Magescas
- Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University
- Boris Duvauchelle
- Morphogenesis, Homoeostasis and Pathologies, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University
- Danielle Canioni
- Department of Paediatric Anatomo-Pathology, Hôpital Necker-Enfants Malades, Sorbonne Paris Cité
- Lucie Sengmanivong
- Membrane Dynamics and Mechanics of Intracellular Signaling Laboratory, Institut Curie–Centre de Recherche, PSL Research University
- Adeline Mayeux
- Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University
- Grégoire Michaux
- Institut de Génétique et Développement de Rennes, CNRS UMR6290
- Florence Campeotto
- Department of Paediatric Gastroenterology, Hôpital Necker-Enfants Malades, Sorbonne Paris Cité
- Julie Lemale
- Department of Pediatric Nutrition and Gastroenterology, Armand-Trousseau Hospital, Assistance Publique-Hôpitaux de Paris, Institute of Cardiometabolism and Nutrition, Pierre et Marie Curie University
- Jérôme Viala
- Department of Pediatric Gastroenterology, Assistance Publique-Hôpitaux de Paris, Robert Debré Hospital, Université Paris Diderot, Sorbonne Paris Cité, UMR843
- Françoise Poirier
- Morphogenesis, Homoeostasis and Pathologies, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University
- Nicolas Minc
- Cellular Spatial Organization, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University
- Jacques Schmitz
- Department of Paediatric Gastroenterology, Hôpital Necker-Enfants Malades, Sorbonne Paris Cité
- Nicole Brousse
- Department of Paediatric Anatomo-Pathology, Hôpital Necker-Enfants Malades, Sorbonne Paris Cité
- Benoit Ladoux
- Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University
- Olivier Goulet
- Department of Paediatric Gastroenterology, Hôpital Necker-Enfants Malades, Sorbonne Paris Cité
- Delphine Delacour
- Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University
- DOI
- https://doi.org/10.1038/ncomms13998
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular junctions, leading to aberrant apical domain and tight junction displacement.
