OXIDATIVE STRESS AND PREECLAMPSIA

Abstract

Preeclampsia is a systemic disease associated with pregnancy, characterized by hypertension, proteinuria, edema and dysfunction of many organs. Recently, the pathogenesis of preeclampsia has been actively studied. It is revealed that an integral part in the development of preeclampsia is oxidative stress. However, until now, researchers can not come to a consensus about the mechanisms of this pathology of pregnant women. The article is devoted to the study of the laws of peroxidation in preeclampsia, depending on the mechanisms of occurrence according to the literature. Articles are taken from the international database PubMed. In the process of studying the literature data of different authors, it was revealed that there are 2 confident points of view on the role of oxidative stress in the pathogenesis of preeclampsia. Some authors believe that oxidative stress induced in the ischemic placenta causes a release of cytotoxic factors into the maternal circulation, stimulating the inflammatory response and activating maternal endothelial cells, which in turn can lead to endothelial dysfunction and, as a result, to the occurrence of preeclampsia. Others believe that the main source of reactive oxygen species during pregnancy is the placenta itself, and their formation increases with PE.

Keywords

• преэклампсия
• окислительный (оксидативный) стресс
• антиоксидантная система
• пероксидация