Infection and Drug Resistance (Apr 2020)

Non-O1, Non-O139 Vibrio cholerae (NOVC) Bacteremia: Case Report and Literature Review, 2015–2019

  • Zhang X,
  • Lu Y,
  • Qian H,
  • Liu G,
  • Mei Y,
  • Jin F,
  • Xia W,
  • Ni F

Journal volume & issue
Vol. Volume 13
pp. 1009 – 1016

Abstract

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Xiaohui Zhang,1,2,* Yanfei Lu,1,2,* Huimin Qian,3 Genyan Liu,1,2 Yaning Mei,1,2 Fei Jin,1,2 Wenying Xia,1,2 Fang Ni1,2 1Department of Laboratory Medicine, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, People’s Republic of China; 2National Key Clinical Department of Laboratory Medicine, Nanjing, People’s Republic of China; 3Key Laboratory of Enteric Pathogenic Microbiology of Ministry of Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenying Xia; Fang NiDepartment of Laboratory Medicine, Jiangsu Province Hospital, Guangzhou Street No. 300, 210029, People’s Republic of ChinaTel +8625-6830-6287Fax +8625-8372-4440Email [email protected]; [email protected]: Non-O1, non-O139 Vibrio cholerae (NOVC) does not agglutinate with O1 and O139 antisera and can cause intestinal and extraintestinal infections in immunocompromised individuals. NOVC bacteremia has the highest mortality among NOVC infections, and the number of reports has increased in recent years. Nevertheless, some clinicians are poorly informed about this disease. Herein, we describe a documented case of NOVC bacteremia in a male patient with impaired liver function. Blood cultures revealed the presence of V. cholerae, but this strain showed self-coagulation on the serum agglutination test. To our knowledge, this phenomenon is unreported among cases of NOVC infections. This pathogen was finally confirmed as NOVC via PCR. Because the patient worked as a garbage transporter, he was likely infected after contact with contaminated water through a foot wound. The patient developed septic shock shortly after admission and ultimately died from the illness. This paper reviews 23 cases of NOVC bacteremia from 2015 to  2019. To improve the accuracy of identifying NOVC and analyze its virulence factors, relevant detection methods were reviewed and analyzed.Keywords: bacteremia, non-O1/non-O139 Vibrio cholerae, V. cholerae, virulence factors

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