Systemic immune-inflammation index combined with quick sequential organ failure assessment score for predicting mortality in sepsis patients
Changya Liu, MD,
Xinxin Wu, MD,
Rou Deng, MS,
Xiangru Xu, MD,
Caiyu Chen, MD,
Linguangjin Wu, MD,
Wen Zhang, MD,
Hongqiang Yang, MS,
Yuerong Fei, MS,
Yuting Sun, MS,
Shuang Zhou, MD,
Bangjiang Fang, MD
Affiliations
Changya Liu, MD
Department of Emergency, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Xinxin Wu, MD
Shanghai Skin Disease Hospital, School of Medicine, Tongji University, 200443, Shanghai, China
Rou Deng, MS
Department of Emergency, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Xiangru Xu, MD
Department of Emergency, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Caiyu Chen, MD
Department of Emergency, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Linguangjin Wu, MD
Department of Emergency, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Wen Zhang, MD
Department of Emergency, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Hongqiang Yang, MS
Department of Emergency, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Yuerong Fei, MS
Department of Emergency, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Yuting Sun, MS
Department of Emergency, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Shuang Zhou, MD
Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Corresponding author. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Bangjiang Fang, MD
Department of Emergency, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; Institute of Emergency and Critical Care Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Corresponding author. Department of Emergency, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Objective: To evaluate the prognostic ability of systemic immune-inflammation index (SII) combine with quick Sequential Organ Failure Assessment (qSOFA) criteria in predicting the 28-day mortality of sepsis. Methods: A retrospective cohort study was conducted, with the population comprised in whom sepsis was confirmed. Clinical and laboratory data recorded were analyzed. The score of Sequential Organ Failure Assessment (SOFA), SII, qSOFA were calculated. Multivariable regression, receiver operating characteristic (ROC) analysis and Kaplan-Meier method were used to identify and compared the predictors of prognosis among SOFA, qSOFA, and the combination of SII with qSOFA. Results: A total of 349 patients admitted from December 2020 and December 2022 were included in the cohort. 95 (27.2%) of whom had died by day 28. The SII, SOFA, and qSOFA scores were significant higher in the non-survivors than that of survivors (P 1.7668) and qSOFA (>1) represented a high risk level in 28-day mortality of sepsis, were performed and identified in Kaplan-Meier survival curves (log-rank test, HR: 6.942, 95% CI: 3.976–12.121; P < 0.0001). Conclusion: The SII in addition to qSOFA provided an effective prognostic tool for predicting mortality in sepsis.
