Decarboxylative tandem C-N coupling with nitroarenes via SH2 mechanism

Shuaishuai Wang; Tingrui Li; Chengyihan Gu; Jie Han; Chuan-Gang Zhao; Chengjian Zhu; Hairen Tan; Jin Xie

doi:10.1038/s41467-022-30176-z

Nature Communications (May 2022)

Decarboxylative tandem C-N coupling with nitroarenes via SH2 mechanism

Shuaishuai Wang,
Tingrui Li,
Chengyihan Gu,
Jie Han,
Chuan-Gang Zhao,
Chengjian Zhu,
Hairen Tan,
Jin Xie

Affiliations

Shuaishuai Wang: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Tingrui Li: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Chengyihan Gu: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Jie Han: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Chuan-Gang Zhao: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Chengjian Zhu: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Hairen Tan: National Laboratory of Solid-State Microstructures, Collaborative Innovation Center of Advanced Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, College of Engineering and Applied Sciences, Nanjing University
Jin Xie: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University

DOI: https://doi.org/10.1038/s41467-022-30176-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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Aromatic tertiary amines are versatile building blocks in organic synthesis. In this article, the authors report on an iron-catalysed reaction for the decarboxylative C-N coupling from carboxylic acids and nitroarenes, leading to non-symmetric tertiary aromatic amines.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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