Stereoselective Synthesis of 4-O-Tosyltetrahydropyrans via Prins Cyclization Reaction of Enol Ethers

Abstract

Abstract Intramolecular cyclization of enol ethers mediated by para-toluenesulfonic acid leads to substituted tetrahydropyrans in good to moderate yields. The reaction is diastereoselective.

Keywords

• tosyl tetrahydropyrans
• prins reaction
• enol ether
• cyclization
• heterocycle