Nature Communications (Nov 2019)
Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch
- Caterina Miro,
- Emery Di Cicco,
- Raffaele Ambrosio,
- Giuseppina Mancino,
- Daniela Di Girolamo,
- Annunziata Gaetana Cicatiello,
- Serena Sagliocchi,
- Annarita Nappi,
- Maria Angela De Stefano,
- Cristina Luongo,
- Dario Antonini,
- Feliciano Visconte,
- Silvia Varricchio,
- Gennaro Ilardi,
- Luigi Del Vecchio,
- Stefania Staibano,
- Anita Boelen,
- Cedric Blanpain,
- Caterina Missero,
- Domenico Salvatore,
- Monica Dentice
Affiliations
- Caterina Miro
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Emery Di Cicco
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Raffaele Ambrosio
- IRCCS SDN
- Giuseppina Mancino
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Daniela Di Girolamo
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Annunziata Gaetana Cicatiello
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Serena Sagliocchi
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Annarita Nappi
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Maria Angela De Stefano
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Cristina Luongo
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- Dario Antonini
- Department of Biology, University of Naples “Federico II”
- Feliciano Visconte
- CEINGE–Biotecnologie Avanzate Scarl
- Silvia Varricchio
- Department of Advanced Biomedical Sciences, University of Naples “Federico II”
- Gennaro Ilardi
- Department of Advanced Biomedical Sciences, University of Naples “Federico II”
- Luigi Del Vecchio
- CEINGE–Biotecnologie Avanzate Scarl
- Stefania Staibano
- Department of Advanced Biomedical Sciences, University of Naples “Federico II”
- Anita Boelen
- Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Center, location AMC
- Cedric Blanpain
- IRIBHM, Université Libre de Bruxelles (ULB)
- Caterina Missero
- Department of Biology, University of Naples “Federico II”
- Domenico Salvatore
- CEINGE–Biotecnologie Avanzate Scarl
- Monica Dentice
- Department of Clinical Medicine and Surgery, University of Naples “Federico II”
- DOI
- https://doi.org/10.1038/s41467-019-13140-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The invasion of epithelial tumours often depends on the epithelial-mesenchymal transition. Here, the authors report that intracellular activation of thyroid hormone by the D2 deiodinase enzyme promotes invasion and progression of squamous cell carcinoma by transcriptionally up-regulating ZEB-1.
