Integrative stemness characteristics associated with prognosis and the immune microenvironment in lung adenocarcinoma

Han Wang; Ying Wang; Wei Luo; Xugang Zhang; Ran Cao; Zhi Yang; Jin Duan; Kun Wang

doi:10.1186/s12890-022-02184-8

BMC Pulmonary Medicine (Dec 2022)

Integrative stemness characteristics associated with prognosis and the immune microenvironment in lung adenocarcinoma

Han Wang,
Ying Wang,
Wei Luo,
Xugang Zhang,
Ran Cao,
Zhi Yang,
Jin Duan,
Kun Wang

Affiliations

Han Wang: Department of Thoracic Surgery, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology
Ying Wang: Department of Thoracic Surgery, Yan’an Hospital of Kunming
Wei Luo: Department of Thoracic Surgery, The Affiliated Anning First People’s Hospital, Kunming University of Science and Technology, Kunming Fourth People’s Hospital
Xugang Zhang: Department of Thoracic Surgery, The Affiliated Anning First People’s Hospital, Kunming University of Science and Technology, Kunming Fourth People’s Hospital
Ran Cao: Department of Thoracic Surgery, The Affiliated Anning First People’s Hospital, Kunming University of Science and Technology, Kunming Fourth People’s Hospital
Zhi Yang: The IVD Medical Marketing Department, 3D Medicines Inc
Jin Duan: Department of Thoracic Surgery, the First Affiliated Hospital of Kunming Medical University
Kun Wang: Department of Thoracic Surgery, The Affiliated Anning First People’s Hospital, Kunming University of Science and Technology, Kunming Fourth People’s Hospital

DOI: https://doi.org/10.1186/s12890-022-02184-8
Journal volume & issue: Vol. 22, no. 1
pp. 1 – 11

Abstract

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Highlights IL-6, FPR2, RLN3 had higher degree in PPI network. The patients in cluster 1 had better prognosis. Total 10 immune checkpoint genes showed higher expression in cluster 1. TMB value in cluster 2 was higher than that in cluster 1.

Published in BMC Pulmonary Medicine

ISSN: 1471-2466 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: http://bmcpulmmed.biomedcentral.com

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Abstract

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