Communications Biology (Apr 2021)

Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS

  • Michael Sloth Trabjerg,
  • Dennis Christian Andersen,
  • Pam Huntjens,
  • Kirsten Egelund Oklinski,
  • Luise Bolther,
  • Jonas Laugård Hald,
  • Amalie Elton Baisgaard,
  • Kasper Mørk,
  • Nikolaj Warming,
  • Ulla Bismark Kullab,
  • Lona John Kroese,
  • Colin Eliot Jason Pritchard,
  • Ivo Johan Huijbers,
  • John Dirk Vestergaard Nieland

DOI
https://doi.org/10.1038/s42003-021-02034-z
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 23

Abstract

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Trabjerg et al. show that the activity of carnitine palmitoyl transferase 1 (CPT1) and lipid metabolism are associated with the disease progression of the SOD1 G93A mouse model mimicking a motor neuron disease Amyotrophic lateral sclerosis (ALS). This study suggests CPT1 as a potential therapeutic target in treating ALS.